Genomatix Genome Analyzer (Two-Day Training)
- Registration Closed
- Oct 25, 2017
- 09:00 AM to 12:00 PM
- NIH Library Training Room
Biology and biological processes are intricately coupled to each other, especially in gene regulation. This concept is reflected in the term “network of networks” for the description of biological events that keep us healthy or disturbances that makes us ill. They have become the hallmark of personalized medicine approaches. A network is a complex structure with multiple links and no pre-defined direction of flow. The actual "flow“ is determined in every instance by the various input parameters of the network. Consequently, whatever changes of biological entities are observed by any experimental technique, including ChIP-seq, should not be treated in isolation. Analysis should include the underlying networks.
As we usually deal with limited changes in a limited environment, it is sufficient to consider the context immediately relevant to the phenomenon observed. However, a whole arsenal of analysis tools has been developed focused on the isolated analysis of a single event (such as a single ChIP-seq experiment). This concept is dated and clashes with the concept of network analysis. This training will focus on some of the most common conceptual clashes, demonstrating solutions based on the network-context concept. The concepts of “relevant context”, “multiple lines of evidence”, and “regulatory network analysis” will be highlighted, and application strategies of the network concept will be illustrated on a few simple examples including a ChIP-on Chip analysis.