Analysis Tools & Databases
The NIH Library licenses a number of bioinformatics tools. The licenses are either floating (access is provided from any NIH computer) and/or static (access is provided from one of the NIH Library Bioinformatics workstations). If you would like to recommend additional resources, please submit a request.
NIH Library Bioinformatics Workstations
The NIH Library provides two workstations to NIH staff that offer access to licensed bioinformatics software programs. These workstations are located in the main reading room, and are dedicated to high-throughput data analysis. To use a workstation, reserve online, call the NIH Library at 301-496-1080, or visit the Information Desk.
| Workstation | Hardware |
|---|---|
| 1 | Windows, 64 bit, 64GB RAM, and 1TB Storage |
| 2 | Windows, 64 bit, 64GB RAM, and 1TB Storage |
Licensed Resources
NOTE: Resources are for NIH staff only.
| Tool | Description |
|---|---|
| CLC Genomics Workbench | CLC Genomics Workbench is software for analyzing and visualizing next generation sequencing data. Its functionality includes de novo assembly of Sanger, 454, Illumina Genome Analyzer and SOLiD data and also de novo assembly from a combination of these platforms. Additionally, it provides contig reports, read mapping, SNP, and DIP detection. |
| Human Gene Mutation Database Professional | The professional version of the Human Gene Mutation Database (HGMD) provides up-to-date information on human inherited gene mutations. It allows researchers to assess the novelty of identified gene mutations. The mutations in the database are manually curated from the scientific literature. They are mapped to the genome and can be searched by motif, type of nucleotide or amino acid substitution, and location within a splice site or regulatory region. |
| Ingenuity Pathways Analysis (IPA) | IPA is a web-based bioinformatics application that allows researchers to upload data analysis results from high-throughput experiments such as microarray and next generation sequencing for functional analyze, integration, and further understanding. This includes both microarray and RNA-Seq gene expression, miRNA, SNP, metabolomics, and proteomics data. In general, lists of genes or chemicals can be analyzed using IPA. It also has a search capability for information on genes, proteins, chemicals, and drugs and allows interactive building of networks to represent biological systems. |
| Lasergene | Lasergene provides users a full range of tools for manipulation of sequence data. Lasergene is applicable to both nucleic acid and protein sequences. Example functions operating on sequences are editing, annotating, virtual cloning, primer design, and SNP discovery. Lasergene is available for PC and Mac platforms. |
| MATLAB (Bioinformatics Toolbox) | MATLAB (matrix laboratory) is a multi-paradigm numerical computing environment. MATLAB allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++,C#,Java,Fortran and Python.
The full MATLAB package includes:
|
| Qiagen Clinical Insight Interpret Translational (QCI-IT) | QCI Interpret Translational is a variant analysis and interpretation tool for basic and translational research involving the analysis of human genetics data and is not intended to be used for diagnostic purposes. QCI Interpret Translational evaluates genomic variants in the context of published/unpublished biomedical evidence, professional association guidelines, publicly available databases, annotations, drug label data, and clinical trials. |